Smads as therapeutic targets for chronic kidney disease
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چکیده
منابع مشابه
Smads as therapeutic targets for chronic kidney disease
Renal fibrosis is a hallmark of chronic kidney disease (CKD). It is generally thought that transforming growth factor-β1 (TGF-β1) is a key mediator of fibrosis and mediates renal scarring positively by Smad2 and Smad3, but negatively by Smad7. Our recent studies found that in CKD, TGF-β1 is not a sole molecule to activate Smads. Many mediators such as angiotensin II and advanced glycation end p...
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ژورنال
عنوان ژورنال: Kidney Research and Clinical Practice
سال: 2012
ISSN: 2211-9132
DOI: 10.1016/j.krcp.2011.12.001